Interaction of haemoglobin with ions binding of inositol hexaphosphate to human haemoglobin a

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The interaction of inositol hexaphosphate with methaemoglobin.

1. Inositol hexaphosphate causes the shape of the oxidation-reduction equilibrium curve to become hyberbolic at acid pH values. 2. Inositol hexaphosphate also causes a decrease in the alkaline oxidation Bohr effect at these same pH values. 3. These results support the idea that inositol hexaphosphate causes methaemoglobin to take up the deoxyhaemoglobin quaternary structure at pH6.5.

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Oxygen-linked binding of halothane to human adult haemoglobin.

The affinity for oxygen of normal human haemoglobin (Hb) solutions was measured in the presence of increasing concentrations of halothane. We observed a maximum increase in P50 of 25% with halothane 40 kPa compared with control (oxygen-argon gas mixtures) indicating the oxygen-linked character of the binding of halothane to the Hb molecule. The effect of halothane on P50 was independent of pH b...

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ژورنال

عنوان ژورنال: FEBS Letters

سال: 1971

ISSN: 0014-5793

DOI: 10.1016/0014-5793(71)80141-2